I chose to immediately write on this topic. An old patient of mine walks in and complains of a back pain. he suffers from IBD (inflammatory bowel disease).
First IBD. in this condition, Diarrhea is a common presentation . Prolonged diarrhea without bleeding but with other features suggestive of inflammatory bowel disease (IBD). Two major forms of this disease are ulcerative colitis (UC) and Crohn disease (CD). Ulcerative colitis is a chronic inflammatory condition characterized by relapsing and remitting episodes of inflammation limited to the mucosal layer of the colon while Crohn disease is characterized by transmural inflammation and by skip lesions.
Some risk factors could be:
- Age and gender
- Racial and ethnicity
- Genetic susceptibility
- Physical activity
spondyloarthritis (SpA, formerly spondyloarthropathy) is often referred to a group of disorders that includes ankylosing ( Causing immobility to the joins) spondylitis or called as (AS). The main forms could be undifferentiated spondyloarthritis (USpA), reactive arthritis (ReA), and the arthritis and spondylitis that may accompany psoriasis and inflammatory bowel diseases (IBD).
How is IBD linked to AS. Gastrointestinal (GI) tract, is There is a strong and well-established association of human leukocyte antigen (HLA)-B27 with ankylosing spondylitis (AS).
I can see of the Labstestsonline that, “With new genetic testing methods, it is now possible to separate HLA-B27 into subtypes. So far, more than 70 different subtypes have been identified, such as HLA B27*05 and HLA B27*02. How the presence of these specific subtypes affects the likelihood of developing an autoimmune disease is not yet known.”
Approximately 90 percent of the risk of developing AS is heritable. At least 30 gene loci have been discovered. The largest contribution is the human leukocyte antigen (HLA)-B27 molecule.