Some common diseases that are caused to to severe vitamin deficiency are vitamin deficiency diseases, such as scurvy (vitamin C), beriberi (thiamine), and pellagra (niacin).
Some common diseases that are caused to to severe vitamin deficiency are vitamin deficiency diseases, such as scurvy (vitamin C), beriberi (thiamine), and pellagra (niacin). However these do not exist in the modern day resource-rich countries. Exceptions however could be in patients with underlying medical disorders or have highly restricted diets, sometimes due to self medication, diets and the like.
On the other hand, controversy continues into whether vitamin supplementation in pharmacologic doses can prevent cancer, heart disease, upper respiratory infections, and other common diseases.
Having said that, one needs to supplement based on the facts and understudying the following parameters:
- Sources off Vitamins in natural diet
- Biochemistry and actions of vitamins inside the human body
- Measurement and signs of any deficiency that may exist.
- Deficiency related to diseases such as Infantile beriberi, Adult beriberi, Syndromes such as Wernicke-Korsakoff syndrome and a few other Thiamine metabolism dysfunction syndromes
- Toxicity is important factor to be noted due to excess vitamin intake or restricted or specific diets.
- Requirements and the limits of vitamin in a healthy body in relation to the height, weight and work profile etc.
To attempt without combinations another way to understand is the diet and where we get these vitamins from. some vitamins against there source and possible disorders is below:
- Thiamin or vitamin B1 is found in larger quantities in foods such as yeast, legumes, pork, rice, and cereals made from whole grains. Deficiency of Thiamin may cause Beriberi, characterized by peripheral neuropathy, with or without edema and heart failure. Another set of possible complication could be Wernicke encephalopathy, characterized by nystagmus, ophthalmoplegia, and ataxia, along with confusion, and Wernicke-Korsakoff syndrome, a chronic neurologic condition.
- Riboflavin or vitamin B2’s source is from meats, fish, eggs and milk, green vegetables, yeast, and enriched foods. Mild deficiency may not be detected as this may not show up any physical signs or symptoms. . However the deficiency (ariboflavinosis) is characterized by sore throat, hyperemia of pharyngeal mucous membranes, edema of mucous membranes, cheilitis, stomatitis, glossitis, normocytic-normochromic anemia, and seborrheic dermatitis.
- Niacin (vitamin B3) is widely received form diet sources of plant and animal foods. Severe deficiency of niacin may cause pellagra, which is characterized by a photosensitive pigmented dermatitis (Sun Exposure), diarrhea, and dementia. Pellagra tends to occur in alcoholics and has been reported as a complication of bariatric surgery or anorexia nervosa. One must watch the supplement doses carefully. It is now well-established that high doses of niacin can act as a antihyperlipidemic agent, decreasing total and low-density lipoprotein (LDL) cholesterol. Side effects at these doses include flushing, nausea, vomiting, pruritus, hives, constipation, and elevation in serum aminotransferases.
- Pantothenic acid or simply as it is called, the vitamin B5 in the diet is mainly in the form of coenzyme A (CoA) and is supplied in egg yolk, liver, kidney, broccoli, and milk. Its deficiency is rare in humans but has been noted in severely malnourished individuals and may cause paresthesias and dysesthesias, known as “burning feet syndrome.”
- Pyridoxine or vitamin B6 is found in the diet in several forms. The source is meats, whole grains, vegetables, and nuts . Deficiencies of vitamin B6 may reflect as as nonspecific stomatitis, glossitis, cheilosis, irritability, confusion, and depression. Toxicity on the other hand at high doses may result in peripheral neuropathy, dermatoses, photosensitivity, dizziness, and nausea.