Brain CholesterolThere are no proven ways to prevent dementia. But here are some things that seem to help keep the brain healthy:

●Physical activity

●A healthy diet

●Social interaction

Small pilot studies of intranasal insulin and dietary manipulation in patients with mild cognitive impairment or AD showing improved cognitive function or biochemical profiles provide further support for the potential link between brain insulin and AD pathogenesis.

The Alzheimer’s Association and the World Dementia Council reviewed the evidence for modifiable risk factors for cognitive decline and dementia and concluded that sufficient evidence supports the link between regular physical activity and management of cardiovascular risk factors (diabetes, obesity, smoking, and hypertension) and reduced risk of cognitive decline and possibly dementia. They also found strong evidence to conclude that a healthy diet and lifelong learning (cognitive training) may also reduce the risk of cognitive decline.

Brain cholesterol metabolism may be an important determinant of AD. The relationship between diet, genetics, blood lipoproteins levels, and AD is complex and inconsistent.

While some epidemiologic studies have reported an association between total or low-density lipoprotein cholesterol (LDL-C) levels, especially in midlife, and risk of AD, the interpretation of these studies is complex. Peripheral blood LDL-C does not cross the blood brain barrier unless the barrier is damaged by factors such as vascular disease. Most of the cholesterol in the brain is synthesized by astrocytes and neurons and provided to brain cells by high-density lipoprotein (HDL) complexes, and there is little or no LDL-C in the brain.

Wish it helps.

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