Spondyloarthritis

I chose to immediately write on this topic. An old patient of mine walks in and complains of a back pain. he suffers from IBD (inflammatory bowel disease).

First IBD. in this condition, Diarrhea is a common presentation . Prolonged diarrhea without bleeding but with other features suggestive of inflammatory bowel disease (IBD). Two major forms of this disease are ulcerative colitis (UC) and Crohn disease (CD). Ulcerative colitis is a chronic inflammatory condition characterized by relapsing and remitting episodes of inflammation limited to the mucosal layer of the colon while Crohn disease is characterized by transmural inflammation and by skip lesions.

Some risk factors could be:

  • Age and gender
  • Racial and ethnicity
  • Genetic susceptibility
  • Smoking
  • Diet
  • Physical activity
  • Obesity
  • Infections

spondyloarthritis (SpA, formerly spondyloarthropathy) is often referred to a group of disorders that includes ankylosing ( Causing immobility to the joins) spondylitis  or called as (AS). The main forms could be undifferentiated spondyloarthritis (USpA), reactive arthritis (ReA), and the arthritis and spondylitis that may accompany psoriasis and inflammatory bowel diseases (IBD).

How is IBD linked to AS.  Gastrointestinal (GI) tract, is There is a strong and well-established association of human leukocyte antigen (HLA)-B27 with ankylosing spondylitis (AS).

I can see of the Labstestsonline that, “With new genetic testing methods, it is now possible to separate HLA-B27 into subtypes. So far, more than 70 different subtypes have been identified, such as HLA B27*05 and HLA B27*02. How the presence of these specific subtypes affects the likelihood of developing an autoimmune disease is not yet known.”

Approximately 90 percent of the risk of developing AS is heritable. At least 30 gene loci have been discovered. The largest contribution is the human leukocyte antigen (HLA)-B27 molecule.

COPD- Chronic obstructive pulmonary disease

copd

COPD is a common respiratory condition involving the airways and characterized by airflow limitation. Several features of COPD patients identify individuals with different prognoses and/or responses to treatment. Whether these features identify separate “phenotypes” of COPD or reflect disease severity remains unclear. However, evaluation of these features can help guide clinical management, and their use in classification of patients is now recommended

Cancer Genomics

Genetics, and genomics, molecular genetic profiling may soon become an integral tool for clinicians to guide individualized management of many medical conditions. Personalized medicine , incorporating genetic and genomic data as well as clinical and environmental factors, to assess individual risks and tailor prevention and disease management strategies.

Advocates for personalized medicine cite its potential to yield significant health and economic benefits:

Improved medical decision making

Delivery of appropriate therapies

Optimized disease prevention strategies

Reduced incidence of treatment-related complications

Reduced healthcare costs

Broadly three types of genetic variation: (i) relatively rare, disease-causing mutations that are associated with Mendelian diseases; (ii) more common variants that are associated with an increased risk of complex diseases; (iii) and sequence variants that modulate drug response (pharmacogenetic variants).

Specific single gene tests — Most gene-specific tests are performed as part of a focused risk evaluation for heritable disease or for diagnostic considerations. Examples include BRCA1 and BRCA2 gene sequencing for carrier identification in at risk individuals with a strong family history of breast cancer and VKORC1 genotyping for warfarin.

Genotyping panels of selected susceptibility variants — These panels are usually bundled as direct-to-consumer (DTC) genetic tests and include single nucleotide polymorphisms (SNPs) that have been associated with common, non-Mendelian or complex traits such as type 2 diabetes, autoimmune disease, and metabolic traits.

Study finds marked benefits for cancer prevention with a higher intake of fatty fish – Medical News Today

Study finds marked benefits for cancer prevention with a higher intake of fatty fish – Medical News Today.

While several other studies have recently challenged the long-held belief of the benefits of a diet high in omega-3fatty acids, this new study led by Saint Luke’s Mid America Heart Institute Cardiovascular Research Scientist James J. DiNicolantonio, PharmD, cites compelling evidence that eating the right kinds of fatty fish, in the right quantity, and prepared the right way, can in fact help prevent the body’s development of adenocarcinomas, a common type of cancerous tumor. A high proportion of the cancers arising in the breast, prostate, pancreas, colon, and the rest of the gastrointestinal tracts are adenocarcinomas.

10 most popular things things that can prevent cancer

Source : American Institute of Cancer Research

Link: http://www.aicr.org/research/research_science_expert_report.html

These ten recommendations for cancer prevention are drawn from the WCRF/AICR Second Expert Report. Each recommendation below links more details.

You can use these links to skip to individual recommendation pages, or you can start with the first and follow links from page to page through the entire list.

  1. Be as lean as possible without becoming underweight.
  2. Be physically active for at least 30 minutes every day.
  3. Avoid sugary drinks. Limit consumption of energy-dense foods.
  4. Eat more of a variety of vegetables, fruits, whole grains and legumes such as beans.
  5. Limit consumption of red meats (such as beef, pork and lamb) and avoid processed meats.
  6. If consumed at all, limit alcoholic drinks to 2 for men and 1 for women a day.
  7. Limit consumption of salty foods and foods processed with salt (sodium).
  8. Don’t use supplements to protect against cancer.
  9. * It is best for mothers to breastfeed exclusively for up to 6 months and then add other liquids and foods.
  10. * After treatment, cancer survivors should follow the recommendations for cancer prevention.

TRUTHS ABOUT SOME COMMON CANCER NUTRITION MYTHS

By Tammy Fansabedian, Registered Dietitian

“Don’t eat sugar, it will make your cancer grow.”
“You have to eat organic.”
“No poultry when you have cancer.”
“Alkaline foods only.”

Do any of these sound familiar? Making sense of all the information on nutrition and cancer that comes our way is difficult. We all have well-meaning friends and family who want to tell us about what their friend’s coworker did to cure “this”, and we are bombarded by the media about products that will cure “that”. These messages are often conflicting, confusing and, unfortunately, incorrect. This misinformation can lead patients and family members to make unnecessary and sometimes harmful decisions about their nutrition and health.

Your healthcare team provides you with only information that has been researched and proven. This is often called “evidence-based”. Here are some common nutrition myths and the facts behind them.

Sugar and Cancer Growth

Lately, one of the most frequent questions I get asked by patients is about sugar and cancer “growth”. The myth is that sugar, a carbohydrate, will make the cancer grow faster than any other nutrient. The truth is that yes, cancer cells do use sugar for energy, but so do all of our healthy cells. Sugar doesn’t make cancer grow faster and depriving it of sugar doesn’t slow the growth.

Eating a lot of refined sugar is not good for our health in part because these foods may cause weight gain. But it’s also important to think about your health status. If you are in treatment and having trouble eating and maintaining your weight, you may not want to restrict your diet even more. It is OK to rely on oatmeal with brown sugar or liquid supplements (like Ensure®) if that’s all you can keep down. These foods are providing you with so many other nutrients like protein, fats, vitamins, and minerals that you need.

Are Organic Foods Better For You?

Organic foods are grown without synthetic fertilizers and pesticides, and are often more expensive than conventionally-grown fruits and vegetables. The cost of organic produce may cause us to buy, and therefore eat, less fruits and vegetables.

There is no research that shows that eating organic foods reduces the risk of cancer. Studies also show that there is no significant difference in the nutritional quality between conventionally grown and organic products. There are so many health and cancer-protecting benefits from the vitamins, minerals and fibre in any form of fruit and vegetable that it would be a shame to restrict intake for the sake of only being able to buy a small amount or selection of the organics. 
Ultimately, deciding to buy organic food is a choice. It may be based on personal beliefs including farming sustainability, but it shouldn’t be based on the basis of gaining more nutrients or reducing cancer risk. Whatever you choose, be sure to wash your fresh produce well!

Alkaline versus Acidic Foods

Some people believe that cancer cells cannot survive in an alkaline environment (the opposite of acidic), and therefore we should eat foods that are more alkaline and not acidic. Unfortunately, most of the “acidic” foods that would be cut out are foods that provide many of us with much-needed protein, like meats and dairy.

More importantly, there are a few key facts that are being overlooked by removing or reducing acidic foods from your diet. There is no evidence to support the fact that eating only alkaline foods will prevent cancer or any other diseases. Our bodies tightly regulate our levels of acidity and we are simply not able to change it by the foods that we eat – and that’s probably a good thing! Cancer cells may not be able to survive in an alkaline environment but neither can our healthy cells.

4 Warning Signs You Should Never Ignore | OPEN Forum

4 Warning Signs You Should Never Ignore | OPEN Forum.

When you’re running your business daily from the weeds, you can’t see the dangers that lie ahead until it’s too late. Look for these 4 warning signs that your business may be in trouble.
SEPTEMBER 10, 2014

It’s tough talking to business owners these days: No one seems to have time anymore because they’re too busy putting out fires in their companies. Whether it’s due to customer complaints, employee issues or problems with vendors, business owners are losing sight of the bigger picture.

Getting Out of the Weeds

This happens when you spend more time working “in” your business, dealing with day-to-day problems, than you do working “on” your business, focusing on the long-term goals and health of your company. It’s a vicious cycle. The more you get caught up in the weeds, only seeing what’s 3 feet in front of you, the more likely something can fall out of the sky and knock you down.

The solution is to periodically position yourself in the clouds for an aerial view, so you can identify the obstacles and opportunities waiting around the bend. You also want to look for certain signs that point to bigger potential problems. As you do this, you’ll find that these signs have cause-and-effect relationships that can help you better manage your business moving forward. They are akin to the light that goes on in your car alerting you that it’s time for an oil change. Heed the warnings and don’t let a $50 annoyance become a $5,000 nightmare.

Trouble on the Horizon

What warning signs should you look for in your company?

1. You lost what you thought was an easy sales win. You thought your latest proposal was a slam dunk until you found out the client chose to go with a competitor. Instead of letting disappointment derail you, look at it as an opportunity to improve your sales process. Ask the client why he didn’t choose your proposal. You should also ask your sales team for its perspective on what went wrong. Analyze what you learn to determine if there are changes you can make to improve the way you work with potential clients in the future.

2. There’s a dip in cash flow. Your business plan is based on estimates of bringing in X amount of dollars per month. One day your bookkeeper says you will be short for the current month. Don’t just address the immediate impact of reduced cash flow. Step back and ask why this happened. How could it have been prevented? Why didn’t you see it coming?

3. “I don’t know what we would do.” If that’s the first thing that crosses your mind as you watch coverage of a natural disaster causing serious damage to homes and businesses, consider it a signal that you need to make sure you have the proper insurance in place before disaster strikes. You also need to recognize that even if you are spared, your customers may be hit and that could have a ripple effect on your business. Think about how you would handle that scenario before you are in the midst of it.

4. There’s uncertainty surrounding your technology. If your computer is wiped out today, would you be able to restore your data tomorrow? The answer should be a confident “yes!” If you hesitated in your answer, then that’s your sign. There are many affordable, easy solutions today that provide secure, reliable backup. There is simply no excuse not to have one. Remember that an external hard drive that you store right next to your computer is just as vulnerable to fire as the computer itself. Also be aware that online thieves are a very real problem for businesses of all sizes. Make sure your system is protected from hackers to minimize the chance of a breach.

A Proactive Approach

Get out of the weeds and take a broader view of your business. Look for signals that point to potential problems. Address the root causes and then establish systems to ensure those same problems don’t arise in the future.

Long-Term Cell Phone Use Linked to Brain Tumor Risk

Long-Term Cell Phone Use Linked to Brain Tumor Risk.

Long-term use of both mobile and cordless phones is associated with an increased risk for glioma, the most common type of brain tumor, the latest research on the subject concludes.

The new study shows that the risk for glioma was tripled among those using a wireless phone for more than 25 years and that the risk was also greater for those who had started using mobile or cordless phones before age 20 years.

“Doctors should be very concerned by this and discuss precautions with their patients,” study author Lennart Hardell, MD, PhD, professor, Department of Oncology, University Hospital, Örebro, Sweden, told Medscape Medical News.

Such precautions, he said, include using hands-free phones with the “loud speaker” feature and text messaging instead of phoning.

The study was published online October 28 in Pathophysiology.

 

Home-Based Therapy Helps Older Adults With Depression, MCI

Home-Based Therapy Helps Older Adults With Depression, MCI.

A home-delivered problem-solving intervention reduces depression and mild cognitive impairment (MCI) in homebound older adults, who often have few treatment options.

In a randomized controlled trial, problem adaptation therapy (PATH) proved more efficacious than supportive therapy for the cognitively impaired (ST-CI) in reducing depression and disability.

“Problem adaptation therapy was more efficacious than ST-CI in reducing depression and disability. Problem adaptation therapy may provide relief to a large group of depressed and cognitively impaired older adults who have few treatment options,” the authors, led by Dimitris N. Kiosses, PhD, of the Weill Cornell Institute of Geriatric Psychiatry in White Plains, New York, write.

The study was published online November 5 in JAMA Psychiatry.

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