More Than 50% of Antipsychotics Prescribed Off Label
More than half of the prescriptions for antipsychotics in the United Kingdom are prescribed to individuals with no diagnosis of a serious mental illness (SMI), a major study of primary care records has revealed.
Investigators at University College London also found that off-label antipsychotic prescribing is more likely to occur in women, older people, and socially and economically disadvantaged individuals.
“In this study of antipsychotic prescribing in a large primary care database representative of the UK, approximately half of the prescriptions for first-generation and second-generation antipsychotics are issued to people who have no record of SMI…in their clinical notes,” the researchers, led by Louise Marston, PhD, write.
“Furthermore, they are more likely to be prescribed to older people, who may be more sensitive to adverse effects such as movement disorders and cardiometabolic risk,” they add.